Environmental factors in epithelial barrier dysfunction
نویسندگان
چکیده
منابع مشابه
Intestinal Epithelial Barrier Dysfunction in Food Hypersensitivity
Intestinal epithelial barrier plays a critical role in the maintenance of gut homeostasis by limiting the penetration of luminal bacteria and dietary allergens, yet allowing antigen sampling for the generation of tolerance. Undigested proteins normally do not gain access to the lamina propria due to physical exclusion by tight junctions at the cell-cell contact sites and intracellular degradati...
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Affiliations: University of Groningen, University Medical Center Groningen, Beatrix Children’s Hospital, Dept of Pediatric Pulmonology and Pediatric Allergology, Groningen, University of Groningen, University Medical Center Groningen, Laboratory of Allergology and Pulmonary Diseases, Dept of Pathology and Medical Biology, Groningen, and GRIAC Research Institute, University of Groningen, Univers...
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BACKGROUND Vitamin D, an important modulator of the immune system, has been shown to protect mucosal barrier homeostasis. This study investigates the effects of vitamin D deficiency on infection-induced changes in intestinal epithelial barrier function in vitro and on Citrobacter rodentium-induced colitis in mice. METHODS Polarized epithelial Caco2-bbe cells were grown in medium with or witho...
متن کاملFactors impacting corneal epithelial barrier function against Pseudomonas aeruginosa traversal.
PURPOSE Mechanisms determining epithelial resistance versus susceptibility to microbial traversal in vivo remain poorly understood. Here, a novel murine model was used to explore factors influencing the corneal epithelial barrier to Pseudomonas aeruginosa penetration. METHODS Murine corneas were blotted with tissue paper before inoculation with green fluorescent protein-expressing P. aerugino...
متن کاملLoss of enteral nutrition in a mouse model results in intestinal epithelial barrier dysfunction.
Total parenteral nutrition (TPN) administration in a mouse model leads to a local mucosal inflammatory response, resulting in a loss of epithelial barrier function (EBF). Although, the underlying mechanisms are unknown, a major contributing factor is a loss of growth factors and subsequent critical downstream signaling. An important component of these is the p-Akt pathway. An additional contrib...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2020
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2020.04.024